4-Acetamidop-Henol Powder Chemical Raw Material Paracetamol CAS 103-90-2

Powder: Yes
CAS 103-90-2
Name 4-Acetamidophenol
Customized: Non-Customized
Certification: GMP, HSE, ISO 9001
Suitable for: Adult
State: Powder
Purity: >99%

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Name 4-Acetamidophenol
CAS 103-90-2 Molecular Weight 151.163
Density 1.3±0.1 g/cm3 Boiling Point 387.8±25.0 °C at 760 mmHg
M F C8H9NO2 Melting Point 168-172 °C(lit.)
  Acetaminophen is an acetanilid antipyretic analgesic. By inhibiting cyclooxygenase, selectively inhibiting the synthesis of prostaglandin in the hypothalamic body temperature regulation center, leading to peripheral vasodilation and sweating to achieve antipyretic effect, the intensity of antipyretic effect is similar to aspirin; by inhibiting the synthesis of prostaglandins, etc. And release, increase the pain threshold and play an analgesic role, which belongs to peripheral analgesics, the effect is weaker than aspirin, only effective for mild to moderate pain. Test Report
Tests Standards Results
Appearance White or almost white ,crystalline powder. White,crystalline powder.
Identification A:IR absorption Complies
  B:UV absorption Complies
  C:TLC Complies
Melting point 168~172°C 169.0~170.9°C
Water Not more than0.5% 0.08%
Related substance ImpurityJ(chloroacetanilide)not more than 10 ppm 2ppm
  Impurity K(4-aminophenolly)not more than 50 ppm 15 ppm
  Impurity F(4-nitrophenolly)not more than 0.05% Not detected
  any other impurity not more than 0.05% 0.01%
  Total of other impurities not more than 0.1% 0.02%
Residue on ignition Not more than 0.1% 0.05%
Chloride Not more than 0.014% Less than 0.014%
Sulfate Not more than 0.02% Less than 0.02%
Sulfide Conforms Conforms
Heavy metals Not more than 0.001% Less than 0.001%
Free p-aminophenol Not more than 0.005% Less than 0.005%
Limit of P-chloroacetanilide Not more than 0.001% Less than 0.001%
Readily carbonizable substances Conforms Conforms
Residual solvents Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5% 0.08%
Assay(anhydrous basis) 99.0~101.0% 99.6%
Conclusion:   Complies with USP34/ BP2011  
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