Products Details
| Product name | Amphotericin B |
| CAS | 1397-89-3 |
| Appearance | white powder |
| Assay | 99% |
| Storage | Cool and Protect from light |
Product Name:Amphotericin B CAS:1397-89-3 MF:C47H73NO17 MW:924.08 EINECS:215-742-2 Mol File:1397-89-3.mol Melting point:>170°C alpha D24 +333° (acidic DMF); -33.6° (0.1N methanolic HCl) Boiling point:804.34°C (rough estimate) Density 1.34 refractive index 1.5280 (estimate) storage temp. 2-8°C solubility sterile water: 20 mg/mL as a stock solution. Stock solutions should be stored at −20?#x00b0;C. Stable at 37?#x00b0;C for 3 days. pkapKa ~5.7(DMF/H2O) (Uncertain) form powder color yellow Water Solubility <0.1 g/100 mL at 21 ºC Contact 
Description Amphotericin B is a polyene macrolide antibiotic which was introduced into clinical medicine in 1955. It is primarily used for the treatment of serious systemic fungal infections. It is also used as an alternative drug for the treatment of drug resistant Leishmania. Amphotericin B is an effective drug, but its use is limited because of its toxicity. The advent of liposome encapsulated amphotericin may increase its use in multiresistant Leishmania in the future[1]. The mechanism of action of amphotericin is as yet not clear. In mycosis it binds to ergosterol present in fungal cell membranes. As a result, the drug forms pores or channels on the cell membrane which disturbs the membrane function allowing electrolytes (particularly potassium) and small molecules to leak from the cell resulting in cell death [2]. Oxidative damage to the cell may also be involved in this process [3]. Its mechanism of action in leishmaniasis may be similar to that in fungi. Anhui Rencheng Technology Co., Ltd. is a company specializing in active pharmaceutical ingredient (API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw material. Our company has always adhered to the company phiosophy of integrity, professionalism, quality first, and customer service. With the efforts of all the company's employees, it has established long-term and stable cooperative relations with many domestic and foreign customers, and won the unanimous trust of domestic and foreign customers. With good comments, our company have made great progress. 
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Description Amphotericin B is a polyene macrolide antibiotic which was introduced into clinical medicine in 1955. It is primarily used for the treatment of serious systemic fungal infections. It is also used as an alternative drug for the treatment of drug resistant Leishmania. Amphotericin B is an effective drug, but its use is limited because of its toxicity. The advent of liposome encapsulated amphotericin may increase its use in multiresistant Leishmania in the future[1]. The mechanism of action of amphotericin is as yet not clear. In mycosis it binds to ergosterol present in fungal cell membranes. As a result, the drug forms pores or channels on the cell membrane which disturbs the membrane function allowing electrolytes (particularly potassium) and small molecules to leak from the cell resulting in cell death [2]. Oxidative damage to the cell may also be involved in this process [3]. Its mechanism of action in leishmaniasis may be similar to that in fungi. Anhui Rencheng Technology Co., Ltd. is a company specializing in active pharmaceutical ingredient (API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw material. Our company has always adhered to the company phiosophy of integrity, professionalism, quality first, and customer service. With the efforts of all the company's employees, it has established long-term and stable cooperative relations with many domestic and foreign customers, and won the unanimous trust of domestic and foreign customers. With good comments, our company have made great progress. 
Packing & Delivery 
Payments